As skin ages, it becomes thinner and more easily damaged. Among other things, skin aging is noted by a decrease in volume and elasticity. There are many internal and external causes to skin aging. For example, aging skin receives less blood flow and lower glandular activity.
Over the years, the skin undergoes a progressive depletion of hyaluronan (HA). This decrease of hyaluronan helps create some signs of aging, moisture loss and thinning of the skin and reduced capacity of the dermis of regenerate. Hyaluronan is found in many tissues of the body, such as skin, cartilage, and the vitreous humour. Therefore, it is well suited to biomedical applications targeting these tissues.